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Atypical and non-classical CD45RB^lo memory B cells are the majority of circulating SARS-CoV-2 specific B cells following mRNA vaccination or COVID-19.

ABSTRACT: Resting memory B cells can be divided into classical or atypical groups, but the heterogenous marker expression on activated memory B cells makes similar classification difficult. Here, by longitudinal analysis of mass cytometry and CITE-seq data from cohorts with COVID-19, bacterial sepsis, or BNT162b2 mRNA vaccine, we observe that resting B cell memory consist of classical CD45RB⁺ memory and CD45RB^lo memory, of which the latter contains of two distinct groups of CD11c⁺ atypical and CD23⁺ non-classical memory cells. CD45RB levels remain stable in these cells after activation, thereby enabling the tracking of activated B cells and plasmablasts derived from either CD45RB⁺ or CD45RB^lo memory B cells. Moreover, in both COVID-19

SUBMITTER: Priest DG

PROVIDER: S-EPMC11315995 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature

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Dataset Information

Atypical and non-classical CD45RB^lo memory B cells are the majority of circulating SARS-CoV-2 specific B cells following mRNA vaccination or COVID-19.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Atypical and non-classical CD45RBlo memory B cells are the majority of circulating SARS-CoV-2 specific B cells following mRNA vaccination or COVID-19.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Atypical and non-classical CD45RB^lo memory B cells are the majority of circulating SARS-CoV-2 specific B cells following mRNA vaccination or COVID-19.