Direct ketone synthesis from primary alcohols and alkenes enabled by a dual photo/cobalt catalysis.

ABSTRACT: Catalytic methods to couple alcohol and alkene feedstocks are highly valuable in synthetic chemistry. The direct oxidative coupling of primary alcohols and alkenes offers a streamlined approach to ketone synthesis. Currently, available methods are based on transition metal-catalyzed alkene hydroacylation, which involves the generation of an electrophilic aldehyde intermediate from primary alcohol dehydrogenation. These methods generally require high reaction temperatures and a high loading of precious metal catalysts and are predominantly effective for branch-selective reactions with electron-rich alkenes. Herein, we designed a dual photo/cobalt-catalytic method to manipulate the reactivity of nucleophilic ketyl radicals for the synthesis of ketones from primary alcohols and alkenes in com

SUBMITTER: Ji G 

PROVIDER: S-EPMC11316105 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature