Functional measures and AD biomarkers among Hispanic and White non-Hispanic older adults.

ABSTRACT:

Introduction

Poorer baseline functioning is associated with long-term cognitive decline among Hispanic older adults, but little is known about associations of these factors with Alzheimer's disease (AD) neuroimaging biomarkers.

Methods

A total of 461 Hispanic and White non-Hispanic (NHW) older adults who are cognitively normal (n = 76), had impaired cognition without mild cognitive impairment (MCI) (n = 41), or carried a diagnosis of MCI (n = 253) or dementia (n = 91) completed neuropsychological and functional assessment, genetic testing, and brain magnetic resonance imaging (MRI). Structural equation modeling (SEM) was used to examine predictive associations between functional and cognitive measures of AD neuroimaging biomarkers.

Results

SUBMITTER: Rodriguez MJ 

PROVIDER: S-EPMC11316142 | biostudies-literature | 2024 Jul-Sep

REPOSITORIES: biostudies-literature