Maternal Adverse Childhood Experiences and Biological Aging During Pregnancy and in Newborns.

ABSTRACT:

Importance

Adverse childhood experiences (ACEs), potentially traumatic experiences occurring before the age of 18 years, are associated with epigenetic aging later in life and may be transmitted across generations.

Objective

To test evidence of the transmission of biological embedding of life experience across generations by analyzing maternal ACEs and epigenetic clocks measured in mothers during pregnancy and in their children at birth.

Design, setting, and participants

For this cross-sectional study, data from the Accessible Resource for Integrated Epigenomic Studies (ARIES) substudy of the Avon Longitudinal Study of Parents and Children (ALSPAC) were analyzed. The ALSPAC study recruited 14 541 women who gave birth in the Avon Health District in the UK between April

SUBMITTER: Dye CK 

PROVIDER: S-EPMC11316241 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature