Genetic susceptibility association between viral infection and colorectal cancer risk: a two-sample Mendelian randomization analysis.

ABSTRACT:

Background

The genetic susceptibility association between viral infection and the risk of colorectal cancer (CRC) has not been established.

Methods

We conducted two-sample Mendelian randomization (MR) analysis using genome-wide association study (GWAS) data. In addition to traditional MR methods, we employed several other approaches, including cML, ConMix, MR-RAPS, and dIVW, to comprehensively assess causal effects. Sensitivity analyses were also performed to ensure the robustness of the results.

Results

After sensitivity analysis, presence of SNPs linked to increased susceptibility to cold sores infection was found to decrease the risk of CRC (OR: 0.73, 95% CI: 0.57-0.93, P = 0.01). In subgroup analysis, presence of SNPs linked to increased susceptibility to viral he

SUBMITTER: Li G 

PROVIDER: S-EPMC11316422 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature