Differential stability of task variable representations in retrosplenial cortex.

ABSTRACT: Cortical neurons store information across different timescales, from seconds to years. Although information stability is variable across regions, it can vary within a region as well. Association areas are known to multiplex behaviorally relevant variables, but the stability of their representations is not well understood. Here, we longitudinally recorded the activity of neuronal populations in the mouse retrosplenial cortex (RSC) during the performance of a context-choice association task. We found that the activity of neurons exhibits different levels of stability across days. Using linear classifiers, we quantified the stability of three task-relevant variables. We find that RSC representations of context and trial outcome display higher stability than motor choice, both at the single ce

SUBMITTER: Franco LM 

PROVIDER: S-EPMC11316801 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature