Heterogeneous brain region-specific responses to astrocytic mitochondrial DNA damage in mice.

ABSTRACT: Astrocytes display context-specific diversity in their functions and respond to noxious stimuli between brain regions. Astrocytic mitochondria have emerged as key players in governing astrocytic functional heterogeneity, given their ability to dynamically adapt their morphology to regional demands on ATP generation and Ca²⁺ buffering functions. Although there is reciprocal regulation between mitochondrial dynamics and mitochondrial Ca²⁺ signaling in astrocytes, the extent of this regulation in astrocytes from different brain regions remains unexplored. Brain-wide, experimentally induced mitochondrial DNA (mtDNA) loss in astrocytes showed that mtDNA integrity is critical for astrocyte function, however, possible diverse responses to this noxious stimulus between brain

SUBMITTER: Ayala DA 

PROVIDER: S-EPMC11316820 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature