Rapid fluctuations in functional connectivity of cortical networks encode spontaneous behavior.

ABSTRACT: Experimental work across species has demonstrated that spontaneously generated behaviors are robustly coupled to variations in neural activity within the cerebral cortex. Functional magnetic resonance imaging data suggest that temporal correlations in cortical networks vary across distinct behavioral states, providing for the dynamic reorganization of patterned activity. However, these data generally lack the temporal resolution to establish links between cortical signals and the continuously varying fluctuations in spontaneous behavior observed in awake animals. Here, we used wide-field mesoscopic calcium imaging to monitor cortical dynamics in awake mice and developed an approach to quantify rapidly time-varying functional connectivity. We show that spontaneous behaviors are represented

SUBMITTER: Benisty H 

PROVIDER: S-EPMC11316935 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature