Co-exposure effects of urinary polycyclic aromatic hydrocarbons and metals on lung function: mediating role of systematic inflammation.

ABSTRACT:

Background

Polycyclic aromatic hydrocarbons (PAHs) and metals were associated with decreased lung function, but co-exposure effects and underlying mechanism remained unknown.

Methods

Among 1,123 adults from National Health and Nutrition Examination Survey 2011-2012, 10 urinary PAHs, 11 urinary metals, and peripheral white blood cell (WBC) count were determined, and 5 lung function indices were measured. Least absolute shrinkage and selection operator, Bayesian kernel machine regression, and quantile-based g-computation were used to estimate co-exposure effects on lung function. Mediation analysis was used to explore mediating role of WBC.

Results

These models demonstrated that PAHs and metals were significantly associated with lung function impairment. Bayesian kernel

SUBMITTER: Wu L 

PROVIDER: S-EPMC11316979 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature