Core biomarkers analysis benefit for diagnosis on human intrahepatic cholestasis of pregnancy.

ABSTRACT:

Background

The pregnant women with intrahepatic cholestasis were at high risk of fetal distress, preterm birth and unexpected stillbirth. Intrahepatic cholestasis of pregnancy (ICP) was mainly caused by disorder of bile acid metabolism, whereas the specific mechanism was obscure.

Methods

We performed proteomics analysis of 10 ICP specimens and 10 placenta specimens from patients without ICP through data-independent acquisition (DIA) technique to disclose differentially expressed proteins. We executed metabolomic analysis of 30 ICP specimens and 30 placenta specimens from patients without ICP through UPLC-MS/MS to identify differentially expressed metabolites. Enrichment and correlation analysis was used to obtain the direct molecular insights of ICP development. The ICP rat

SUBMITTER: Fang Y 

PROVIDER: S-EPMC11317000 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature