Parsing the roles of DExD-box proteins DDX39A and DDX39B in alternative RNA splicing.

ABSTRACT: DExD-box RNA proteins DDX39A and DDX39B are highly homologous paralogs that are conserved in vertebrates. They are required for energy-driven reactions involved in RNA processing. Although we have some understanding of how their functions overlap in RNA nuclear export, our knowledge of whether or not these proteins have specific or redundant functions in RNA splicing is limited. Our previous work has shown that DDX39B is responsible for regulating the splicing of important immune transcripts IL7R and FOXP3. In this study, we aimed to investigate whether DDX39A, a highly homologous paralog of DDX39B, plays a similar role in regulating alternative RNA splicing. We find that DDX39A and DDX39B have significant redundancy in their gene targets, but there are targets that uniquely require one or

SUBMITTER: Banerjee S 

PROVIDER: S-EPMC11317157 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature