CB2 stimulation of adipose resident ILC2s orchestrates immune balance and ameliorates type 2 diabetes mellitus.

ABSTRACT: Development of type 2 diabetes mellitus (T2DM) is associated with low-grade chronic type 2 inflammation and disturbance of glucose homeostasis. Group 2 innate lymphoid cells (ILC2s) play a critical role in maintaining adipose homeostasis via the production of type 2 cytokines. Here, we demonstrate that CB₂, a G-protein-coupled receptor (GPCR) and member of the endocannabinoid system, is expressed on both visceral adipose tissue (VAT)-derived murine and human ILC2s. Moreover, we utilize a combination of ex vivo and in vivo approaches to explore the functional and therapeutic impacts of CB₂ engagement on VAT ILC2s in a T2DM model. Our results show that CB₂ stimulation of ILC2s protects against insulin-resistance onset, ameliorates glucose tolerance, and rever

SUBMITTER: Shafiei-Jahani P 

PROVIDER: S-EPMC11317174 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature