Causal gene identification using mitochondria-associated genome-wide mendelian randomization in atrial fibrillation.

ABSTRACT: Background: Mitochondrial dysfunction is one of the important patho-mechanisms in the development of atrial fibrillation (AF) with underidentified genetic pathophysiology. Methods: Summarized data of methylation, expression and protein abundance levels of mitochondria-related genes were obtained from corresponding studies, respectively. Genes related to mitochondria dysfunction in associations with AF were obtained from the UK Biobank (discovery), and the FinnGen study (replication). Summary-data-based Mendelian randomization analysis (SMR) was performed to assess potential causal relationships between mitochondria-related genes related to the molecular features of AF. Colocalization analysis was further conducted to assess whether the identified signal pairs shared causal ge

SUBMITTER: Chen Y 

PROVIDER: S-EPMC11317256 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature