Age and Vasodilator Response to Different Hyperemic Agents: Adenosine versus Contrast Medium.

ABSTRACT:

Background

Age-related remodelling has the potential to affect the microvascular response to hyperemic stimuli. However, its precise effects on the vasodilatory response to adenosine and contrast medium, as well as its influence on fractional flow reserve (FFR) and contrast fractional flow reserve (cFFR), have not been previously investigated. We investigate the impact of age on these indices.

Methods

We extrapolated data from the post-revascularization optimization and physiological evaluation of intermediate lesions using fractional flow reserve (PROPHET-FFR) and The Multi-center Evaluation of the Accuracy of the Contrast MEdium INduced Pd/Pa RaTiO in Predicting (MEMENTO) studies. Only lesions with a relevant vasodilatory response to adenosine and contrast medium were cons

SUBMITTER: Galante D 

PROVIDER: S-EPMC11317353 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature