<i>Pseudomonas aeruginosa</i> mucinous phenotypes and <i>algUmucABD</i> operon mutant characteristics obtained from inpatients with bronchiectasis and their correlation with acute aggravation.

ABSTRACT:

Objective

Although the mechanism is unclear, Pseudomonas aeruginosa (PA) infection directly affects the frequency of acute exacerbations in patients with bronchiectasis. The aims of this article are to analyze the genetic mutation characteristics of the algUmucABD operon in PA, isolated from hospitalized patients with bronchiectasis, and to explore independent risk factors for frequent acute exacerbations of bronchiectasis.

Methods

Based on the number of acute exacerbations that occurred in the past year, these patients with bronchiectasis were divided into those with frequent acute exacerbations (Group A) and those with non-frequent acute exacerbations (Group B). We identified the distribution of mucoid phenotypes (MPs) and alginate morphotypes (AMs) in PA, an

SUBMITTER: Tan Y 

PROVIDER: S-EPMC11317387 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature