Exploring the causal effect of placental physiology in susceptibility to mental and addictive disorders: a Mendelian randomization study.

ABSTRACT:

Background

Epidemiological studies have linked low birth weight to psychiatric disorders, including substance use disorders. Genomic analyses suggest a role of placental physiology on psychiatric risk. We investigated whether this association is causally related to impaired trophoblast function.

Methods

We conducted a two-sample summary-data Mendelian randomization study using as instrumental variables those genetic variants strongly associated with birth weight, whose effect is exerted through the fetal genome, and are located near genes with differential expression in trophoblasts. Eight psychiatric and substance use disorders with >10,000 samples were included as outcomes. The inverse variance weighted method was used as the main analysis and several sensitivity analyses

SUBMITTER: Jacome-Ferrer P 

PROVIDER: S-EPMC11317394 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature