The HUNT lung-SNP model: genetic variants plus clinical variables improve lung cancer risk assessment over clinical models.

ABSTRACT:

Purpose

The HUNT Lung Cancer Model (HUNT LCM) predicts individualized 6-year lung cancer (LC) risk among individuals who ever smoked cigarettes with high precision based on eight clinical variables. Can the performance be improved by adding genetic information?

Methods

A polygenic model was developed in the prospective Norwegian HUNT2 study with clinical and genotype data of individuals who ever smoked cigarettes (n = 30749, median follow up 15.26 years) where 160 LC were diagnosed within six years. It included the variables of the original HUNT LCM plus 22 single nucleotide polymorphisms (SNPs) highly associated with LC. External validation was performed in the prospective Norwegian Tromsø Study (n = 2663).

Results

The novel HUNT Lung-SNP model significantly improved

SUBMITTER: Nguyen OTD 

PROVIDER: S-EPMC11317451 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature