Longitudinal controlled attenuation parameter and liver stiffness in children with and without perinatal HIV infection in South Africa.

ABSTRACT:

Objectives

Metabolic dysfunction-associated steatotic liver disease (MASLD) is an emerging cause of liver disease in HIV. Transient elastography (TE) with controlled attenuation parameter (CAP) measures liver stiffness as a marker of liver fibrosis and CAP as a measure of hepatic steatosis. Our aim was to evaluate longitudinal CAP and liver stiffness in children with perinatally acquired HIV (PHIV) on antiretroviral therapy (ART) from early life compared to children without HIV (HU).

Design

Prospective cohort study.

Methods

PHIV and HU were followed annually for two years. During the study, 60% of PHIV switched from older ART regimens to tenofovir disoproxil, lamivudine and dolutegravir (TLD). Longitudinal evolution of CAP and liver stiffness were investigated in two

SUBMITTER: Rose PC 

PROVIDER: S-EPMC11317452 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature