The role of the ALKBH5 RNA demethylase in invasive breast cancer.

ABSTRACT:

Background

N6-methyladenosine (m⁶A) is the most common internal RNA modification and is involved in regulation of RNA and protein expression. AlkB family member 5 (ALKBH5) is a m⁶A demethylase. Given the important role of m⁶A in biological mechanisms, m⁶A and its regulators, have been implicated in many disease processes, including cancer. However, the contribution of ALKBH5 to invasive breast cancer (BC) remains poorly understood. The aim of this study was to evaluate the clinicopathological value of ALKBH5 in BC.

Methods

Publicly available data were used to investigate ALKBH5 mRNA alterations, prognostic significance, and association with clinical parameters at the genomic and transcriptomic level. Differentially expressed genes

SUBMITTER: Woodcock CL 

PROVIDER: S-EPMC11317455 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature