Gastroesophageal reflux disease and risk for arrhythmias: a Mendelian randomization analysis.

ABSTRACT:

Background

Clinical observations and epidemiological studies suggest a potential linkage between gastroesophageal reflux disease (GERD) and arrhythmias, yet the underlying mechanism remains elusive. This study investigates the causal relationship between GERD and four types of arrhythmia through a genetic lens, employing Mendelian randomization analysis to elucidate the directionality of these associations.

Methods

Selected single nucleotide polymorphisms (SNPs) from genome-wide association study (GWAS) data were utilized as instrumental variables. The inverse variance weighting (IVW) method, MR-Egger regression analysis, and the weighted median method were employed in two-sample Mendelian randomization analysis. Horizontal pleiotropy was detected and corrected using the MR-

SUBMITTER: Liang J 

PROVIDER: S-EPMC11317468 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature