Association between weight change and serum anti-aging protein α-Klotho: a cross-sectional study in middle-aged and older adults.

ABSTRACT: The relationship of weight change has extended to accelerated ageing, yet little is known about the association between weight change and anti-aging protein α-Klotho. This study included 10,972 subjects from the National Health and Nutrition Examination Survey 2007-2016. Participants were measured body weight and height at baseline and recalled weight at young adulthood and middle adulthood. α-Klotho concentrations were quantified. Generalized linear regression models were used to assess the association between weight change and α-Klotho. Across adulthood, maximal overweight, non-obese to obese, and stable obesity were consistently associated with lower serum Klotho levels. Compared with participants who remained at normal weight, from middle to late adulthood, participants experiencing ma

SUBMITTER: Chen S 

PROVIDER: S-EPMC11317480 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature