Effects of a high-fat diet on cognition and brain distribution of intranasal insulin in E3 and E4 male and female mice.

ABSTRACT: There are genetic and environmental risk factors that contribute to the development of cognitive decline in Alzheimer's disease (AD). Some of these include the genetic predisposition of the apolipoprotein E4 genotype, consuming a high-fat diet (HFD), and the female sex. Brain insulin receptor resistance and deficiency have also been shown to be associated with AD and cognitive impairment. Intranasal (INL) insulin enhances cognition in AD, but the response varies due to genotype, diet, and sex. We investigated here the combination of these risk factors in a humanized mouse model, expressing E3 or E4, following a HFD in males and females on cognitive performance and the brain distribution of insulin following INL delivery. The HFD had a negative effect on survival in male mice only, requirin

SUBMITTER: Chaklai A 

PROVIDER: S-EPMC11317510 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature