Convergent evolution in toxin detection and resistance provides evidence for conserved bacterial-fungal interactions.

ABSTRACT: Microbes rarely exist in isolation and instead form complex polymicrobial communities. As a result, microbes have developed intricate offensive and defensive strategies that enhance their fitness in these complex communities. Thus, identifying and understanding the molecular mechanisms controlling polymicrobial interactions is critical for understanding the function of microbial communities. In this study, we show that the gram-negative opportunistic human pathogen Pseudomonas aeruginosa, which frequently causes infection alongside a plethora of other microbes including fungi, encodes a genetic network which can detect and defend against gliotoxin, a potent, disulfide-containing antimicrobial produced by the ubiquitous filamentous fungus Aspergillus fumigatus. We show that gl

SUBMITTER: Dolan SK 

PROVIDER: S-EPMC11317636 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature