Long-term cost-effectiveness of insertion of a biological mesh during stoma-site closure: 5-8-year follow-up of the ROCSS randomized controlled trial.

ABSTRACT:

Background

The original ROCSS trial demonstrated a significant reduction in clinically detectable incisional hernias at 2 years in patients receiving prophylactic biological mesh during stoma closure. ROCSS-Ex was designed to investigate the 5-8-year cost-effectiveness of mesh in the surviving cohort using an abdominal wall-specific quality of life score.

Methods

Eligible participants from original UK centres were identified. The primary outcome (abdominal wall-specific quality of life) was measured using the HerQLes score and EQ-5D-5L. Assessors remained blind to patients' original allocation, even if the patient was aware of their treatment.

Results

Of the original 790 patients, 598 were available for long-term follow-up. HerQLes scores were available for 396 patien

SUBMITTER: Reinforcement of Closure of Stoma Site (ROCSS) Collaborative and West Midlands Research Collaborative 

PROVIDER: S-EPMC11317774 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature