CA125 outperforms NT-proBNP in the prediction of maximum aerobic capacity in heart failure with preserved ejection fraction and kidney dysfunction.

ABSTRACT:

Background

Heart failure with preserved ejection fraction (HFpEF) often coexists with chronic kidney disease (CKD). Exercise intolerance is a major determinant of quality of life and morbidity in both scenarios. We aimed to evaluate the associations between N-terminal pro-B-type natriuretic peptide (NT-proBNP) and carbohydrate antigen 125 (CA125) with maximal aerobic capacity (peak VO₂) in ambulatory HFpEF and whether these associations were influenced by kidney function.

Methods

This single-centre study prospectively enrolled 133 patients with HFpEF who performed maximal cardiopulmonary exercise testing. Patients were stratified across estimated glomerular filtration rate (eGFR) categories (<60 ml/min/1.73 m² versus ≥60 ml/min/1.73 m²).

R

SUBMITTER: Nunez-Marin G 

PROVIDER: S-EPMC11317843 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature