Syntheses and biological activities of calix[4]resorcinarene derivatives modified by sulfonic acid and sulfonamides.

ABSTRACT: Functionalization of C-propyl-resorcinolcalix[4]arene (1a) and C-iso-butyl-resorcinolcalix[4]arene (1b) with sodium sulfite and formaldehyde solution gave two corresponding sulfonatomethylated calix[4]resorcinarenes 2a/b. Further modification of 2a/b with different primary amines afforded three calix[4]resorcinarene sulfonamides 3a/b and 4c. Antibacterial and antitumor tests were performed on the starting calix[4]resorcinarenes and their sulfonic acid and sulfonamide derivatives. The results showed that in terms of antimicrobial activity calix[4]resorcinarenes and their derivatives showed bacteriostatic activity against both Escherichia coli and Staphylococcus aureus. Of which compound 1b was the most effective against Escherichia coli with a MIC value of

SUBMITTER: Ye X 

PROVIDER: S-EPMC11317879 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature