Interaction of a caffeine overdose with clinical doses of contraceptive ethinyl estradiol in a young woman.

ABSTRACT:

Aim

The overdose of caffeine, a cytochrome P450 1A2 probe, in young women has become a problem. The aim of this study was to evaluate possible drug interactions between intentionally overdosed caffeine (12 g) and oral contraceptive doses of ethinyl estradiol prescribed to a young woman in a suicide attempt.

Methods

The serum concentrations of caffeine in the patient and the time-dependent ethinyl estradiol inhibition of caffeine oxidation in vitro were evaluated.

Results

The serum concentration of caffeine 4 h after overdose was 136 μg/mL; from the data obtained between 4 and 28 h after overdose, the half-life was estimated to be 33 h, which is many times larger than the normal value. Prescribed ethinyl estradiol prolonged caffeine elimination in vivo and inhibited pa

SUBMITTER: Adachi K 

PROVIDER: S-EPMC11317924 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature