Fluorescent Peptides Sequester Redox Copper to Mitigate Oxidative Stress, Amyloid Toxicity, and Neuroinflammation.

ABSTRACT: Alzheimer's disease is a progressive neurodegenerative disorder that significantly contributes to dementia. The lack of effective therapeutic interventions presents a significant challenge to global health. We have developed a set of short peptides (PN_Gln) conjugated with a dual-functional fluorophoric amino acid (N_Gln). The lead peptide, P2N_Gln, displays a high affinity for Cu²⁺, maintaining the metal ion in a redox-inactive state. This mitigates the cytotoxicity generated by reactive oxygen species (ROS), which are produced by Cu²⁺ under the reductive conditions of Asc and Aβ₁₆ or Aβ₄₂. Furthermore, P2N_Gln inhibits both Cu-dependent and -independent fibrillation of Aβ₄₂, along with the subs

SUBMITTER: Mandal S 

PROVIDER: S-EPMC11318102 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature