CYB561 is a potential therapeutic target for breast cancer and is associated with immune cell infiltration.

ABSTRACT:

Background

Breast cancer (BC), a common malignant tumor originating from the terminal ductal lobular unit of the breast, poses a substantial health risk to women. Previous studies have associated cytochrome b561 (CYB561) with a poor prognosis in BC; however, its underlying mechanism of this association remains unclear.

Methods

We investigated the expression of CYB561 mRNA in BC using databases such as The Cancer Genome Atlas, Gene Expression Omnibus, Tumor-Normal-Metastatic plot, and Kaplan-Meier plotter databases. The prognostic value of CYB561 protein in BC was assessed in relation to its expression levels in tumor tissue samples from 158 patients with BC. The effect of CYB561 on BC progression was confirmed using in vivo and in vitro experiments. The biological functions

SUBMITTER: Zhuo J 

PROVIDER: S-EPMC11318125 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature