Age-dependent changes in phagocytic activity: in vivo response of mouse pulmonary antigen presenting cells to direct lung delivery of charged PEGDA nanoparticles.

ABSTRACT:

Background

Current needle-based vaccination for respiratory viruses is ineffective at producing sufficient, long-lasting local immunity in the elderly. Direct pulmonary delivery to the resident local pulmonary immune cells can create long-term mucosal responses. However, criteria for drug vehicle design rules that can overcome age-specific changes in immune cell functions have yet to be established.

Results

Here, in vivo charge-based nanoparticle (NP) uptake was compared in mice of two age groups (2- and 16-months) within the four notable pulmonary antigen presenting cell (APC) populations: alveolar macrophages (AM), interstitial macrophages (IM), CD103⁺ dendritic cells (DCs), and CD11b⁺ DCs. Both macrophage populations exhibited preferential uptake of

SUBMITTER: Sudduth ER 

PROVIDER: S-EPMC11318229 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature