Causal influence of immune factors on the risk of diabetic retinopathy: a mendelian randomization study.

ABSTRACT:

Objectives

Diabetic retinopathy (DR) is a prevalent microvascular complication in diabetic patients. Various mechanisms have been implicated in the pathogenesis of DR. Previous studies have observed the relationship between immune factors and DR, but the causal relationship has not been determined.

Methods

We conducted a two-sample Mendelian randomization (MR) analysis of 731 immune cells and DR, using publicly available genome-wide association study (GWAS) summary statistics, to evaluate potential causal relationships between them. Four types of immune traits were included in the analysis through flow cytometry. GWAS statistics for DR were obtained from the Finngen database, which performed GWAS on 190,594 European individuals (Ncase = 14,584, Ncontrol = 176,010) to assess

SUBMITTER: Li Y 

PROVIDER: S-EPMC11318264 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature