Ocular and Serum Profiles of Inflammatory Molecules Associated With Retinitis Pigmentosa.

ABSTRACT:

Purpose

To investigate the profiles and correlations between local and systemic inflammatory molecules in patients with retinitis pigmentosa (RP).

Methods

The paired samples of aqueous humor and serum were collected from 36 eyes of 36 typical patients with RP and 25 eyes of age-matched patients with cataracts. The concentration of cytokines/chemokines was evaluated by a multiplexed immunoarray (Q-Plex). The correlations between ocular and serum inflammatory molecules and their association with visual function were analyzed.

Results

The aqueous levels of IL-6, Eotaxin, GROα, I-309, IL-8, IP-10, MCP-1, MCP-2, RANTES, and TARC were significantly elevated in patients with RP compared to controls (all P < 0.05). The detection rate of aqueous IL-23 was higher in patients wi

SUBMITTER: Tao Y 

PROVIDER: S-EPMC11318359 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature