The benefit of favorable venous outflow profile is mediated through reduced microvascular dysfunction in acute ischemic stroke.

ABSTRACT:

Introductions

Venous outflow (VO) is emerging as a marker of microvascular integrity in acute ischemic stroke. Using hemorrhagic transformation (HT) and infarct growth as mediators, we tested whether a favorable VO profile benefited functional outcome by reducing consequences of microvascular dysfunction.

Patients and methods

Patients receiving thrombectomy in three comprehensive stroke centers due to acute anterior circulation occlusion were included. VO was assessed semi-quantitatively by the opacification of ipsilateral vein of Labbé, Trolard and superficial middle cerebral vein. HT was graded on follow-up CT. Infarct growth volume (IGV) was the difference of final infarct volume and baseline core volume. The association of VO and functional independence (90-day modified

SUBMITTER: Li S 

PROVIDER: S-EPMC11318418 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature