EVRC: reconstruction of chromosome 3D structure models using error-vector resultant algorithm with clustering coefficient.

ABSTRACT:

Motivation

Reconstruction of 3D structure models is of great importance for the study of chromosome function. Software tools for this task are highly needed.

Results

We present a novel reconstruction algorithm, called EVRC, which utilizes co-clustering coefficients and error-vector resultant for chromosome 3D structure reconstruction. As an update of our previous EVR algorithm, EVRC now can deal with both single and multiple chromosomes in structure modeling. To evaluate the effectiveness and accuracy of the EVRC algorithm, we applied it to simulation datasets and real Hi-C datasets. The results show that the reconstructed structures have high similarity to the original/real structures, indicating the effectiveness and robustness of the EVRC algorithm. Furthermore, we applie

SUBMITTER: Wang X 

PROVIDER: S-EPMC11318666 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature