Transcriptomics-based characterization of the immuno-stromal microenvironment in pediatric low-grade glioma.

ABSTRACT: Immunologic treatment options are uncommon in low-grade gliomas, although such therapies might be beneficial for inoperable and aggressive cases. Knowledge of the immune and stromal cells in low-grade gliomas is highly relevant for such approaches but still needs to be improved. Published gene-expression data from 400 low-grade gliomas and 193 high-grade gliomas were gathered to quantify 10 microenvironment cell populations with a deconvolution method designed explicitly for brain tumors. First, we investigated general differences in the microenvironment of low- and high-grade gliomas. Lower-grade and high-grade tumors cluster together, respectively, and show a general similarity within and distinct differences between these groups, the main difference being a higher infiltration of fibrob

SUBMITTER: Korner M 

PROVIDER: S-EPMC11318680 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature