Anti-Mullerian hormone and fertility in women after childhood cancer treatment: Association with current infertility risk classifications.

ABSTRACT:

Background

To identify childhood cancer survivors (CCSs) at risk of premature ovarian insufficiency (POI) and impaired fertility is important given its impact on quality of life. The aim of this study was to assess ovarian markers and fertility outcomes in adult female CCSs. We used the Swedish and the PanCareLIFE classifications for infertility risk grouping.

Methods

167 CCSs, at median age 34.6 years (19.3-57.8) with a median follow-up time of 25.4 years (11.6-41.3), and 164 healthy matched controls were included in this cross-sectional study. We assessed anti-Müllerian hormone (AMH) levels, antral follicle count (AFC), ovarian volume (OV), and fertility outcomes. Based on gonadotoxic treatments given, CCSs were categorized into infertility risk groups.

Results

The

SUBMITTER: Nystrom A 

PROVIDER: S-EPMC11318921 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature