Semaphorin7A patterns neural circuitry in the lateral line of the zebrafish.

ABSTRACT: In a developing nervous system, axonal arbors often undergo complex rearrangements before neural circuits attain their final innervation topology. In the lateral line sensory system of the zebrafish, developing sensory axons reorganize their terminal arborization patterns to establish precise neural microcircuits around the mechanosensory hair cells. However, a quantitative understanding of the changes in the sensory arbor morphology and the regulators behind the microcircuit assembly remain enigmatic. Here, we report that Semaphorin7A (Sema7A) acts as an important mediator of these processes. Utilizing a semi-automated three-dimensional neurite tracing methodology and computational techniques, we have identified and quantitatively analyzed distinct topological features that shape the netw

SUBMITTER: Dasgupta A 

PROVIDER: S-EPMC11318972 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature