Plasma aldosterone concentrations elevation in hypertensive patients: the dual impact on hyperuricemia and gout.

ABSTRACT:

Background

Prior research has highlighted the association between uric acid (UA) and the activation of the renin-angiotensin-aldosterone system (RAAS). However, the specific relationship between aldosterone, the RAAS's end product, and UA-related diseases remains poorly understood. This study aims to clarify the impact of aldosterone on the development and progression of hyperuricemia and gout in hypertensive patients.

Methods

Our study involved 34534 hypertensive participants, assessing plasma aldosterone concentration (PAC)'s role in UA-related diseases, mainly hyperuricemia and gout. We applied multiple logistic regression to investigate the impact of PAC and used restricted cubic splines (RCS) for examining the dose-response relationship between PAC and these diseases. T

SUBMITTER: Song S 

PROVIDER: S-EPMC11319118 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature