ANO7 African-ancestral genomic diversity and advanced prostate cancer.

ABSTRACT:

Background

Prostate cancer (PCa) is a significant health burden for African men, with mortality rates more than double global averages. The prostate specific Anoctamin 7 (ANO7) gene linked with poor patient outcomes has recently been identified as the target for an African-specific protein-truncating PCa-risk allele.

Methods

Here we determined the role of ANO7 in a study of 889 men from southern Africa, leveraging exomic genotyping array PCa case-control data (n = 780, 17 ANO7 alleles) and deep sequenced whole genome data for germline and tumour ANO7 interrogation (n = 109), while providing clinicopathologically matched European-derived sequence data comparative analyses (n = 57). Associated predicted deleterious variants (PDVs) were further assessed for impact using computa

SUBMITTER: Jiang J 

PROVIDER: S-EPMC11319200 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature