The YTH domain-containing protein family: Emerging players in immunomodulation and tumour immunotherapy targets.

ABSTRACT:

Background

The modification of N6-methyladenosine (m6A) plays a pivotal role in tumor by altering both innate and adaptive immune systems through various pathways, including the regulation of messenger RNA. The YTH domain protein family, acting as "readers" of m6A modifications, affects RNA splicing, stability, and immunogenicity, thereby playing essential roles in immune regulation and antitumor immunity. Despite their significance, the impact of the YTH domain protein family on tumor initiation and progression, as well as their involvement in tumor immune regulation and therapy, remains underexplored and lacks comprehensive review.

Conclusion

This review introduces the molecular characteristics of the YTH domain protein family and their physiological and pathological roles

SUBMITTER: Li F 

PROVIDER: S-EPMC11319238 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature