Dataset Information

Memory function in autoimmune encephalitis: a cross-sectional prospective study utilising multiple memory paradigms.

ABSTRACT:

Background and objective

Autoimmune encephalitis (AE) is often associated with clinically significant memory impairment. This study aimed to evaluate memory in a cross-sectional prospective AE cohort using multiple memory paradigms.

Methods

52 patients (50% seropositive) meeting Graus criteria for possible AE were prospectively recruited between October 2019 and August 202. A comprehensive examination of memory was performed, including tests of supraspan verbal memory (list learning), logicosemantic memory (story learning), figural memory (learning of geometric designs), and verbal associative learning (verbal paired associates). Memory scores were compared to demographically adjusted normative data. Pattern analysis was conducted to assist in the identification of patterns in memory performances.

Results

Mean memory scores were not significantly below the normative mean. At an individual patient level, over 20% of the cohort exhibited impaired delayed figural memory, supraspan verbal memory learning and recall. Observed performances were significantly below expected performance for story learning (p = 0.017) and recall (p = 0.003), figural recall (p < 0.0001), initial acquisition (p < 0.001) and final acquisition of a list (p < 0.001) and all delayed recall measures of the list (p < 0.00001). 54.76% of patients exhibited intact psychometrics, and 16 distinct patterns of impairment emerged, indicating variability in memory outcomes.

Discussion

While statistical evidence for memory impairment did not emerge at an aggregate level, a proportion of patients present with evidence of abnormal memory performance on psychometrics. Variability in impaired memory measures argues for an individualised patient-focused approach to clinical assessment in AE. Future research should validate these findings with a larger sample size and explore the relationships between memory profiles and other cognitive functions.

SUBMITTER: Griffith SP

PROVIDER: S-EPMC11319369 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature

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Publications

Memory function in autoimmune encephalitis: a cross-sectional prospective study utilising multiple memory paradigms.

Griffith Sarah P SP Wesselingh Robb R Seery Nabil N Rushen Tiffany T Kyndt Chris C Long Brian B Seneviratne Udaya U Kalincik Tomas T Buzzard Katherine K Butzkueven Helmut H O'Brien Terence J TJ Alpitsis Rubina R Malpas Charles B CB Monif Mastura M

Journal of neurology 20240625 8

<h4>Background and objective</h4>Autoimmune encephalitis (AE) is often associated with clinically significant memory impairment. This study aimed to evaluate memory in a cross-sectional prospective AE cohort using multiple memory paradigms.<h4>Methods</h4>52 patients (50% seropositive) meeting Graus criteria for possible AE were prospectively recruited between October 2019 and August 202. A comprehensive examination of memory was performed, including tests of supraspan verbal memory (list learni ...[more]

PMID: 38918245

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Dataset Information

Memory function in autoimmune encephalitis: a cross-sectional prospective study utilising multiple memory paradigms.

Background and objective

Methods

Results

Discussion

Publications

Memory function in autoimmune encephalitis: a cross-sectional prospective study utilising multiple memory paradigms.

Similar Datasets

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