Repeated cognitive assessments show stable function over time in patients with ALS.

ABSTRACT:

Background

Amyotrophic lateral sclerosis (ALS) is a multisystem disorder with not only motor symptoms but also extra-motor features including cognitive impairment. The most common cognitive profile observed in patients with ALS includes deficits in executive function, language, and social cognition. However, longitudinal studies on cognitive changes over time in ALS are sparse. We aimed to investigate the presence and nature of cognitive impairment at the time of ALS diagnosis and its association with survival as well as explore longitudinal cognitive change.

Method

Patients (n = 216) were recruited at the Karolinska University Hospital in Stockholm, Sweden. Follow-up visits (n = 307 in total) were performed every 6 months. Cognitive impairment was assessed using the Edinbur

SUBMITTER: Oijerstedt L 

PROVIDER: S-EPMC11319384 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature