Dataset Information

Exploring the causal association between frailty index with the common types of arthritis: a Mendelian randomization analysis.

ABSTRACT:

Background

Previous observational studies indicated a complex association between frailty and arthritis.

Aims

To investigate the genetic causal relationship between the frailty index and the risk of common arthritis.

Methods

We performed a large-scale Mendelian randomization (MR) analysis to assess frailty index associations with the risk of common arthritis in the UK Biobank (UKB), and the FinnGen Biobank. Summary genome-wide association statistics for frailty, as defined by the frailty index, and common arthritis including rheumatoid arthritis (RA), osteoarthritis (OA), psoriatic arthritis (PSA), and ankylosing spondylitis (AS). The inverse-variance weight (IVW) method served as the primary MR analysis. Heterogeneity testing and sensitivity analysis were also conducted.

Results

Our results denoted a genetic association between the frailty index with an increased risk of OA, the odds ratio (OR)_IVW in the UKB was 1.03 (95% confidence interval [CI]: 1.01-1.05; P = 0.007), and OR_IVW was 1.55 (95% CI: 1.16-2.07; P = 0.003) in the FinnGen. For RA, the OR_IVW from UKB and FinnGen were 1.03 (1.01-1.05, P = 0.006) and 4.57 (1.35-96.49; P = 0.025) respectively. For PSA, the frailty index was associated with PSA (OR_IVW = 4.22 (1.21-14.67), P = 0.023) in FinnGen, not in UKB (P > 0.05). However, no association was found between frailty index and AS (P > 0.05). These results remained consistent across sensitivity assessments.

Conclusion

This study demonstrated a potential causal relationship that genetic predisposition to frailty index was associated with the risk of arthritis, especially RA, OA, and PSA, not but AS. Our findings enrich the existing body of knowledge on the subject matter.

SUBMITTER: Sun W

PROVIDER: S-EPMC11319416 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature

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Publications

Exploring the causal association between frailty index with the common types of arthritis: a Mendelian randomization analysis.

Sun Weichu W Xiao Hui H Li Yayun Y

Aging clinical and experimental research 20240812 1

<h4>Background</h4>Previous observational studies indicated a complex association between frailty and arthritis.<h4>Aims</h4>To investigate the genetic causal relationship between the frailty index and the risk of common arthritis.<h4>Methods</h4>We performed a large-scale Mendelian randomization (MR) analysis to assess frailty index associations with the risk of common arthritis in the UK Biobank (UKB), and the FinnGen Biobank. Summary genome-wide association statistics for frailty, as defined ...[more]

PMID: 39133382

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Project description:ObjectiveWhether rheumatoid arthritis patients have an increased risk of cervical cancer remains controversial, and further research is needed on this clinical question. This study aims to investigate the association between rheumatoid arthritis and the susceptibility to cervical cancer by employing Mendelian randomization methodology, utilizing the extensive dataset from human genome-wide association data analysis.MethodsThe publicly accessible MR base database was utilized to obtain the complete genome, relevant research findings, and summarized data pertaining to rheumatoid arthritis and cervical cancer. Genetic tool variables, specifically single-nucleotide polymorphisms closely linked to rheumatoid arthritis, were chosen for analysis. Four methods, namely inverse variance weighted analysis, weighted median analysis, weighted mode, and MR-Egger regression, were employed. Statistical analysis was conducted to explore the potential association between rheumatoid arthritis and susceptibility to cervical cancer.ResultsThe results of the inverse variance weighted analysis (OR = 1.096, 95% CI: 1.018-1.180, P = 0.015) indicate a significant causal relationship between rheumatoid arthritis and an increased risk of cervical cancer. Furthermore, the absence of horizontal pleiotropic effects (MR-Egger intercept = 0.00025, P = 0.574) and heterogeneity (QEgger = 2.239, I2Egger = 0.225, PEgger = 0.268, QIVW = 2.734, I2IVW = 0.220, PIVW = 0.999) suggests that the observed association is not influenced by confounding factors. Sensitivity analysis and other statistical methods also support the conclusion that genetic pleiotropy does not introduce bias to the findings.ConclusionThere is a causal relationship between rheumatoid arthritis and the occurrence of cervical cancer. People with rheumatoid arthritis is one of the high-risk groups for early screening of cervical cancer. The IL-18 may play a significant role in elevating the risk of cervical cancer among rheumatoid arthritis patients.

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Dataset Information

Exploring the causal association between frailty index with the common types of arthritis: a Mendelian randomization analysis.

Background

Aims

Methods

Results

Conclusion

Publications

Exploring the causal association between frailty index with the common types of arthritis: a Mendelian randomization analysis.

Similar Datasets

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