Progression independent of relapse activity in relapsing multiple sclerosis: impact and relationship with secondary progression.

ABSTRACT:

Objectives

We investigated the occurrence and relative contribution of relapse-associated worsening (RAW) and progression independent of relapse activity (PIRA) to confirmed disability accrual (CDA) and transition to secondary progression (SP) in relapsing multiple sclerosis (MS).

Methods

Relapsing-onset MS patients with follow-up > / = 5 years (16,130) were extracted from the Italian MS Registry. CDA was a 6-month confirmed increase in Expanded Disability Status Scale (EDSS) score. Sustained disability accumulation (SDA) was a CDA with no EDSS improvement in all subsequent visits. Predictors of PIRA and RAW and the association between final EDSS score and type of CDA were assessed using logistic multivariable regression and multivariable ordinal regression models, respectiv

SUBMITTER: Portaccio E 

PROVIDER: S-EPMC11319422 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature