Refining pain management in mice by comparing multimodal analgesia and NSAID monotherapy for neurosurgical procedures.

ABSTRACT: While neurosurgical interventions are frequently used in laboratory mice, refinement efforts to optimize analgesic management based on multimodal approaches appear to be rather limited. Therefore, we compared the efficacy and tolerability of combinations of the non-steroidal anti-inflammatory drug carprofen, a sustained-release formulation of the opioid buprenorphine, and the local anesthetic bupivacaine with carprofen monotherapy. Female and male C57BL/6J mice were subjected to isoflurane anesthesia and an intracranial electrode implant procedure. Given the multidimensional nature of postsurgical pain and distress, various physiological, behavioral, and biochemical parameters were applied for their assessment. The analysis revealed alterations in Neuro scores, home cage locomotion, body w

SUBMITTER: Munk A 

PROVIDER: S-EPMC11319454 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature