Dataset Information

Validation of a risk score to differentiate autoimmune and viral encephalitis: a Nationwide Cohort Study in Denmark.

ABSTRACT:

Background

A score to differentiate autoimmune (AE) and viral encephalitis (VE) early upon admission has recently been developed but needed external validation. The objective of this study was to evaluate the performance of the score in a larger and more diagnostically diverse patient cohort.

Methods

We conducted a retrospective nationwide and population-based cohort study including all adults with encephalitis of definite viral (2015-2022) or autoimmune aetiology (2009-2022) in Denmark. Variables included in the score-model were extracted from patient records and individual risk scores were assessed. The performance of the score was assessed by receiver-operating characteristics (ROC) curve analyses and calculation of the area under the curve (AUC).

Results

A total of 496 patients with encephalitis [AE n = 90, VE n = 287 and presumed infectious encephalitis (PIE) n = 119] were included in the study. The score was highly accurate in predicting cases of AE reaching an AUC of 0.94 (95% CI 0.92-0.97). Having a score ≥ 3 predicted AE with a PPV of 87% and an NPV of 91%. The risk score was found to perform well across aetiological subgroups and applied to the PIE cohort resulted in an AUC of 0.88 (95% CI 0.84-0.93).

Conclusion

The excellent performance of the score as reported in the development study was confirmed in this significantly larger and more diverse cohort of patients with encephalitis in Denmark. These results should prompt further prospective testing with wider inclusion criteria.

SUBMITTER: Fjordside L

PROVIDER: S-EPMC11319475 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature

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Publications

Validation of a risk score to differentiate autoimmune and viral encephalitis: a Nationwide Cohort Study in Denmark.

Fjordside Lasse L Nissen Mette Scheller MS Florescu Anna Maria AM Storgaard Merete M Larsen Lykke L Wiese Lothar L von Lüttichau Hans Rudolf HR Jepsen Micha Phill Grønholm MPG Hansen Birgitte Rønde BR Andersen Christian Østergaard CØ Bodilsen Jacob J Nielsen Henrik H Blaabjerg Morten M Lebech Anne-Mette AM Mens Helene H

Journal of neurology 20240518 8

<h4>Background</h4>A score to differentiate autoimmune (AE) and viral encephalitis (VE) early upon admission has recently been developed but needed external validation. The objective of this study was to evaluate the performance of the score in a larger and more diagnostically diverse patient cohort.<h4>Methods</h4>We conducted a retrospective nationwide and population-based cohort study including all adults with encephalitis of definite viral (2015-2022) or autoimmune aetiology (2009-2022) in D ...[more]

PMID: 38761191

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Dataset Information

Validation of a risk score to differentiate autoimmune and viral encephalitis: a Nationwide Cohort Study in Denmark.

Background

Methods

Results

Conclusion

Publications

Validation of a risk score to differentiate autoimmune and viral encephalitis: a Nationwide Cohort Study in Denmark.

Similar Datasets

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