Genome-wide association studies of coffee intake in UK/US participants of European ancestry uncover cohort-specific genetic associations.

ABSTRACT: Coffee is one of the most widely consumed beverages. We performed a genome-wide association study (GWAS) of coffee intake in US-based 23andMe participants (N = 130,153) and identified 7 significant loci, with many replicating in three multi-ancestral cohorts. We examined genetic correlations and performed a phenome-wide association study across hundreds of biomarkers, health, and lifestyle traits, then compared our results to the largest available GWAS of coffee intake from the UK Biobank (UKB; N = 334,659). We observed consistent positive genetic correlations with substance use and obesity in both cohorts. Other genetic correlations were discrepant, including positive genetic correlations between coffee intake and psychiatric illnesses, pain, and gastrointestinal traits in 23andMe that we

SUBMITTER: Thorpe HHA 

PROVIDER: S-EPMC11319477 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature