MyD88 in osteoclast and osteoblast lineages differentially controls bone remodeling in homeostasis and malaria.

ABSTRACT: Chronic bone loss is an under-recognized complication of malaria, the underlying mechanism of which remains incompletely understood. We have previously shown that persistent accumulation of Plasmodium products in the bone marrow leads to chronic inflammation in osteoblast (OB) and osteoclast (OC) precursors causing bone loss through MyD88, an adaptor molecule for diverse inflammatory signals. However, the specific contribution of MyD88 signaling in OB or OC precursors in malaria-induced bone loss remains elusive. To assess the direct cell-intrinsic role of MyD88 signaling in adult bone metabolism under physiological and infection conditions, we used the Lox-Cre system to specifically deplete MyD88 in the OB or OC lineages. Mice lacking MyD88 primarily in the maturing OBs showed a comparabl

SUBMITTER: Alshaweesh J 

PROVIDER: S-EPMC11319481 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature