Antibiotic resistance gene dynamics in the commensal infant gut microbiome over the first year of life.

ABSTRACT: Colonization of the infant gut is an important developmental process characterized by high carriage of antimicrobial resistance genes (ARGs) and high abundances of pathobionts. The horizontal transfer of ARGs to pathogenic bacteria represents a major public health concern. However, there is still a paucity of longitudinal studies surveilling ARGs in healthy infant guts at high temporal resolution. Furthermore, we do not yet have a clear view of how temporal variation in ARG carriage relates to the dynamics of specific bacterial populations, as well as community virulence potential. Here, we performed deep shotgun metagenomic sequencing of monthly fecal samples from a cohort of 12 infants, covering the first year of life to interrogate the infant gut microbiome for ARG content. We further r

SUBMITTER: Trosvik P 

PROVIDER: S-EPMC11319485 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature