Platelet transcription factors license the pro-inflammatory cytokine response of human monocytes.

ABSTRACT: In humans, blood Classical CD14⁺ monocytes contribute to host defense by secreting large amounts of pro-inflammatory cytokines. Their aberrant activity causes hyper-inflammation and life-threatening cytokine storms, while dysfunctional monocytes are associated with 'immunoparalysis', a state of immune hypo responsiveness and reduced pro-inflammatory gene expression, predisposing individuals to opportunistic infections. Understanding how monocyte functions are regulated is critical to prevent these harmful outcomes. We reveal platelets' vital role in the pro-inflammatory cytokine responses of human monocytes. Naturally low platelet counts in patients with immune thrombocytopenia or removal of platelets from healthy monocytes result in monocyte immunoparalysis, marked by impaired

SUBMITTER: Hawwari I 

PROVIDER: S-EPMC11319489 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature